Nanodrug applications in photodynamic therapy.
نویسندگان
چکیده
Photodynamic therapy (PDT) has developed over last century and is now becoming a more widely used medical tool having gained regulatory approval for the treatment of various diseases such as cancer and macular degeneration. It is a two-step technique in which the delivery of a photosensitizing drug is followed by the irradiation of light. Activated photosensitizers transfer energy to molecular oxygen which results in the generation of reactive oxygen species which in turn cause cells apoptosis or necrosis. Although this modality has significantly improved the quality of life and survival time for many cancer patients it still offers significant potential for further improvement. In addition to the development of new PDT drugs, the use of nanosized carriers for photosensitizers is a promising approach which might improve the efficiency of photodynamic activity and which can overcome many side effects associated with classic photodynamic therapy. This review aims at highlighting the different types of nanomedical approaches currently used in PDT and outlines future trends and limitations of nanodelivery of photosensitizers.
منابع مشابه
Nanotechnology; its significance in cancer and photodynamic therapy
In the last decade, developments in nanotechnology have provided a new field in medicine called “Nanomedicine”. Nanomedicine has provided new tools for photodynamic therapy. Quantum dots (QDs) are approximately spherical nanoparticles that have attracted broad attention and have been used in nanomedicine applications. QDs have high molar extinction coefficients and photoluminescence quantum yie...
متن کاملPhotodynamic Therapy: A New Approach to Remove Embryos of the Wistar Rat
Background Photodynamic therapy (PDT) is a promising new cancer treatment strategy which inactivates tumor cells by simultaneoulsy using light and a photosensitizer. The similarity between tumors and newly implanted embryos is notable. Extrauterine pregnancy (EUP) does not have a definite treatment and previous therapeutic options (medical and surgical) have not been effective or suitable. Ther...
متن کاملSelective aggregation of PAMAM dendrimer nanocarriers and PAMAM/ZnPc nanodrugs on human atheromatous carotid tissues: a photodynamic therapy for atherosclerosis
Photodynamic therapy (PDT) involves the action of photons on photosensitive molecules, where atomic oxygen or OH(-) molecular species are locally released on pathogenic human cells, which are mainly carcinogenic, thus causing cell necrosis. The efficacy of PDT depends on the local nanothermodynamic conditions near the cell/nanodrug system that control both the level of intracellular translocati...
متن کاملApplications of nanotechnology in endodontic: A Review
Owing to its favorable impacts on the properties of materials, nanotechnology is rapidly growing. Adding nano particles to a material can significantly affect its mechanical and physical properties. In recent years, nanotechnology has been applied in the field of medical sciences in order to enhance the quality of treatment procedures. This technology can be used in various aspects of dentistry...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Photodiagnosis and photodynamic therapy
دوره 8 1 شماره
صفحات -
تاریخ انتشار 2011